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Mouse Anti-NSF Recombinant Antibody (4E164) (CBMAB-N0541-WJ)

This product is a Mouse antibody that recognizes NSF. The antibody 4E164 can be used for immunoassay techniques such as: IP, WB.
See all NSF antibodies

Summary

Host Animal
Mouse
Specificity
Cattle, Dog, Chicken, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep
Clone
4E164
Antibody Isotype
IgG2b, κ
Application
IP, WB

Basic Information

Specificity
Cattle, Dog, Chicken, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1mM PMSF, 50% glycerol
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N-Ethylmaleimide Sensitive Factor, Vesicle Fusing ATPase
Introduction
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).
Entrez Gene ID
Human4905
Mouse18195
Rat60355
Chicken419972
Cattle504457
Hamster100770898
Monkey715297
Dog490921
Pig100624659
Rabbit100353806
Sheep101120344
UniProt ID
HumanP46459
MouseP46460
RatQ9QUL6
ChickenE1BQU4
CattleF1MZU2
HamsterP18708
MonkeyF6YT14
DogE2RFV4
PigF1RRS3
RabbitG1T845
SheepW5PMS2
Alternative Names
N-Ethylmaleimide Sensitive Factor, Vesicle Fusing ATPase; N-Ethylmaleimide-Sensitive Factor-Like Protein; N-Ethylmaleimide-Sensitive Fusion Protein; Vesicular-Fusion Protein NSF; NEM-Sensitive Fusion Protein; EC 3.6.4.6;
Function
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).
Biological Process
ExocytosisManual Assertion Based On ExperimentTAS:UniProtKB
Golgi to plasma membrane protein transportManual Assertion Based On ExperimentIBA:GO_Central
Intra-Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Intracellular protein transportManual Assertion Based On ExperimentIMP:CACAO
Plasma membrane fusionManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of receptor recyclingManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transportIEA:Ensembl
Regulation of exocytosisISS:ParkinsonsUK-UCL
SNARE complex disassemblyISS:ParkinsonsUK-UCL
Vesicle-mediated transportISS:ParkinsonsUK-UCL
Cellular Location
Cytoplasm
Involvement in disease
Developmental and epileptic encephalopathy 96 (DEE96):
A form of epileptic encephalopathy, a heterogeneous group of early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE96 is an autosomal dominant form characterized by onset of seizures in the first days or weeks of life. Affected infants also have hypotonia with respiratory insufficiency that may result in premature death.
PTM
Phosphorylation at Ser-569 interferes with homohexamerization.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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