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Mouse Anti-NSF Monoclonal Antibody (NSF-1) (CBMAB-1432-YC)

Provided herein is a mouse monoclonal antibody against Human NSF. The antibody, clone NSF-1, can be used for immunoassay techniques, such as FC, ICC, IF, IHC-P, IP and WB.
See all NSF antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Chicken, Cattle
Clone
NSF-1
Antibody Isotype
IgG
Application
FC, ICC, IF, IHC-P, IP, WB

Basic Information

Immunogen
Recombinant full length human protein
Specificity
Human, Mouse, Rat, Chicken, Cattle
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N-Ethylmaleimide Sensitive Factor, Vesicle Fusing ATPase
Introduction
NSF catalyzes the fusion of transport vesicles within the Golgi cisternae. NSF is required for vesicle-mediated transport and transport from the endoplasmic reticulum to the Golgi stack.
Entrez Gene ID
Human4905
Mouse18195
Rat60355
Chicken419972
Cattle504457
UniProt ID
HumanP46459
MouseP46460
RatQ9QUL6
ChickenE1BQU4
CattleF1MZU2
Alternative Names
SKD2; SEC18
Function
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).
Biological Process
ExocytosisManual Assertion Based On ExperimentTAS:UniProtKB
Golgi to plasma membrane protein transportManual Assertion Based On ExperimentIBA:GO_Central
Intra-Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Intracellular protein transportManual Assertion Based On ExperimentIMP:CACAO
Plasma membrane fusionManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of receptor recyclingManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transportIEA:Ensembl
Regulation of exocytosisISS:ParkinsonsUK-UCL
SNARE complex disassemblyISS:ParkinsonsUK-UCL
Vesicle-mediated transportISS:ParkinsonsUK-UCL
Cellular Location
Cytoplasm
Involvement in disease
Developmental and epileptic encephalopathy 96 (DEE96):
A form of epileptic encephalopathy, a heterogeneous group of early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE96 is an autosomal dominant form characterized by onset of seizures in the first days or weeks of life. Affected infants also have hypotonia with respiratory insufficiency that may result in premature death.
PTM
Phosphorylation at Ser-569 interferes with homohexamerization.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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