PGA4
PGA4 is a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins.
Full Name
Pepsinogen 4, group I (pepsinogen A)
Function
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Biological Process
DigestionIEA:UniProtKB-KW
Cellular Location
Secreted
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Anti-PGA4 antibodies
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Target: PGA4
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: 961902
Application*: WB, IH
Target: PGA4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G9
Application*: E, IF, WB
Target: PGA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D1C6
Application*: E
Target: PGA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C1
Application*: E, IH, WB
Target: PGA4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1020
Application*: WB, P, IF, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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