PHACTR4

PHACTR4 is a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1.

Full Name

Phosphatase And Actin Regulator 4

Function

Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).

Biological Process

Actin cytoskeleton organizationISS:UniProtKB
Closure of optic fissureISS:UniProtKB
Enteric nervous system developmentISS:UniProtKB
Negative regulation of integrin-mediated signaling pathwayISS:UniProtKB
Neural crest cell migrationISS:UniProtKB
Neural tube closureISS:UniProtKB
Positive regulation of catalytic activityISS:UniProtKB
Regulation of cell cycleISS:UniProtKB
Rho protein signal transductionISS:UniProtKB

Cellular Location

Cytoplasm
Cell projection, lamellipodium