Rabbit Anti-PHACTR4 Recombinant Antibody (CBYC-P341) (CBMAB-P1638-YC)

Name: Rabbit Anti-PHACTR4 Recombinant Antibody (CBYC-P341)
SKU: CBMAB-P1638-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBYC-P341

Application

WB, IHC-P, FC, ICC, IF

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Phosphatase And Actin Regulator 4

Introduction

PHACTR4 is a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1.

Entrez Gene ID

65979

UniProt ID

Q8IZ21

Alternative Names

Phosphatase And Actin Regulator 4; Protein Phosphatase 1, Regulatory Subunit 124; PPP1R124;

Function

Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).

Biological Process

Actin cytoskeleton organizationISS:UniProtKB
Closure of optic fissureISS:UniProtKB
Enteric nervous system developmentISS:UniProtKB
Negative regulation of integrin-mediated signaling pathwayISS:UniProtKB
Neural crest cell migrationISS:UniProtKB
Neural tube closureISS:UniProtKB
Positive regulation of catalytic activityISS:UniProtKB
Regulation of cell cycleISS:UniProtKB
Rho protein signal transductionISS:UniProtKB

Cellular Location

Cytoplasm
Cell projection, lamellipodium

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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