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Rabbit Anti-PHACTR4 Recombinant Antibody (CBYC-P341) (CBMAB-P1638-YC)

Provided herein is a Rabbit monoclonal antibody against Human Phosphatase And Actin Regulator 4. The antibody can be used for immunoassay techniques, such as WB, IHC-P, FC, ICC, IF.
See all PHACTR4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYC-P341
Antibody Isotype
IgG
Application
WB, IHC-P, FC, ICC, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphatase And Actin Regulator 4
Introduction
PHACTR4 is a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1.
Entrez Gene ID
65979
UniProt ID
Q8IZ21
Alternative Names
Phosphatase And Actin Regulator 4; Protein Phosphatase 1, Regulatory Subunit 124; PPP1R124;
Function
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).
Biological Process
Actin cytoskeleton organizationISS:UniProtKB
Closure of optic fissureISS:UniProtKB
Enteric nervous system developmentISS:UniProtKB
Negative regulation of integrin-mediated signaling pathwayISS:UniProtKB
Neural crest cell migrationISS:UniProtKB
Neural tube closureISS:UniProtKB
Positive regulation of catalytic activityISS:UniProtKB
Regulation of cell cycleISS:UniProtKB
Rho protein signal transductionISS:UniProtKB
Cellular Location
Cytoplasm
Cell projection, lamellipodium
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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