Phospho-STAT6 (Tyr641)

Full Name

Function

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.

Biological Process

Cellular response to hydrogen peroxideIEA:Ensembl
Cellular response to reactive nitrogen speciesIEA:Ensembl
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentIBA:GO_Central
Gene expressionIEA:Ensembl
Growth hormone receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Interleukin-4-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Mammary gland epithelial cell proliferationIEA:Ensembl
Mammary gland morphogenesisIEA:Ensemblegative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of type 2 immune responseIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of isotype switching to IgE isotypesIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
T-helper 1 cell lineage commitmentIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus
Translocated into the nucleus in response to phosphorylation.

PTM

Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300).
Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity).
Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).
Mono-ADP-ribosylated by PARP14.