PPP1R13B

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq]

Full Name

protein phosphatase 1, regulatory (inhibitor) subunit 13B

Function

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540).
Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.

Biological Process

Intrinsic apoptotic signaling pathway by p53 class mediatorManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell cycleManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Predominantly cytoplasmic. Some fraction is nuclear.