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Mouse Anti-PPP1R13B Recombinant Antibody (6H1) (CBMAB-P2598-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Phosphatase 1 Regulatory Subunit 13B. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PPP1R13B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6H1
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein phosphatase 1, regulatory (inhibitor) subunit 13B
Introduction
PPP1R13B is a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
Entrez Gene ID
23368
UniProt ID
Q96KQ4
Alternative Names
p53BP2-like; ASPP1; p85
Function
Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540).
Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.
Biological Process
Intrinsic apoptotic signaling pathway by p53 class mediatorManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell cycleManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Predominantly cytoplasmic. Some fraction is nuclear.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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