PPP2R1B

PPP2R1B is a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.

Full Name

Protein Phosphatase 2 Scaffold Subunit Abeta

Function

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.

Biological Process

Apoptotic process involved in morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandManual Assertion Based On ExperimentIMP:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

cytoplasm
extracellular exosome
membrane raft
protein phosphatase type 2A complex