PRDX5

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]

Full Name

PRDX5

Function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

Biological Process

Cell redox homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to oxidative stressManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to reactive oxygen speciesManual Assertion Based On ExperimentIMP:UniProtKB
Hydrogen peroxide catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB
NADPH oxidationIDA:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of oxidoreductase activityIDA:UniProtKB
Negative regulation of transcription by RNA polymerase IIIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of collagen biosynthetic processIDA:UniProtKB
Reactive nitrogen species metabolic processIDA:UniProtKB
Regulation of apoptosis involved in tissue homeostasisIDA:UniProtKB
Response to oxidative stressManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Isoform Mitochondrial
Mitochondrion
Isoform Cytoplasmic+peroxisomal
Cytoplasm
Peroxisome matrix
Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5.

PTM

S-palmitoylated (PubMed:31740833).
Palmitoylation occurs on the active site, inhibiting its reactivity; therefore PRDX5 palmitoylation status determines its antioxidant capacity (PubMed:31740833).
Isoform Mitochondrial
S-palmitoylated (PubMed:31740833).
Depalmitoylated by ABHD10 (PubMed:31740833).