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Mouse Anti-PRDX5 Recombinant Antibody (3E6) (CBMAB-A7014-LY)

The product is antibody recognizes PRDX5. The antibody 3E6 immunoassay techniques such as: sELISA, ELISA.
See all PRDX5 antibodies
Published Data
Fig.1 MCF-7 cells express elevated levels of Prdx proteins.
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Fig.2 Effect of Prdx suppression on doxorubicin-induced toxicity.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3E6
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
PRDX5 (NP_036226, 105 a.a. ~ 214 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PRDX5
Introduction
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
Entrez Gene ID
25824
UniProt ID
P30044
Alternative Names
ACR1; AOEB166; B166; MGC117264; MGC142283; MGC142285; PLP; PMP20; PRDX6; PRXV; SBBI10
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Biological Process
Cell redox homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to oxidative stressManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to reactive oxygen speciesManual Assertion Based On ExperimentIMP:UniProtKB
Hydrogen peroxide catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB
NADPH oxidationIDA:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of oxidoreductase activityIDA:UniProtKB
Negative regulation of transcription by RNA polymerase IIIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of collagen biosynthetic processIDA:UniProtKB
Reactive nitrogen species metabolic processIDA:UniProtKB
Regulation of apoptosis involved in tissue homeostasisIDA:UniProtKB
Response to oxidative stressManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Isoform Mitochondrial
Mitochondrion
Isoform Cytoplasmic+peroxisomal
Cytoplasm
Peroxisome matrix
Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5.
PTM
S-palmitoylated (PubMed:31740833).
Palmitoylation occurs on the active site, inhibiting its reactivity; therefore PRDX5 palmitoylation status determines its antioxidant capacity (PubMed:31740833).
Isoform Mitochondrial
S-palmitoylated (PubMed:31740833).
Depalmitoylated by ABHD10 (PubMed:31740833).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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