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Mouse Anti-PRDX5 Recombinant Antibody (12A) (CBMAB-P2746-YC)

Provided herein is a Mouse monoclonal antibody against Human Peroxiredoxin 5. The antibody can be used for immunoassay techniques, such as WB, ELISA, IHC-P.
See all PRDX5 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
12A
Antibody Isotype
IgG2a
Application
WB, ELISA, IHC-P

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PRDX5
Introduction
PRDX5 (Peroxiredoxin 5) is a protein coding gene. Diseases associated with PRDX5 include Fuchs' Endothelial Dystrophy and Corticobasal Degeneration. Among its related pathways are Gene Expression and Folate Metabolism. Gene Ontology annotations related to this gene include signaling receptor binding and protein dimerization activity.
Entrez Gene ID
Human25824
Mouse54683
Rat113898
UniProt ID
HumanP30044
MouseP99029
RatQ9R063
Alternative Names
ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20; PRDX6; PRXV; SBBI10; prx-V
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Biological Process
Cell redox homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to oxidative stressManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to reactive oxygen speciesManual Assertion Based On ExperimentIMP:UniProtKB
Hydrogen peroxide catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB
NADPH oxidationIDA:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of oxidoreductase activityIDA:UniProtKB
Negative regulation of transcription by RNA polymerase IIIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of collagen biosynthetic processIDA:UniProtKB
Reactive nitrogen species metabolic processIDA:UniProtKB
Regulation of apoptosis involved in tissue homeostasisIDA:UniProtKB
Response to oxidative stressManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Isoform Mitochondrial
Mitochondrion
Isoform Cytoplasmic+peroxisomal
Cytoplasm
Peroxisome matrix
Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5.
PTM
S-palmitoylated (PubMed:31740833).
Palmitoylation occurs on the active site, inhibiting its reactivity; therefore PRDX5 palmitoylation status determines its antioxidant capacity (PubMed:31740833).
Isoform Mitochondrial
S-palmitoylated (PubMed:31740833).
Depalmitoylated by ABHD10 (PubMed:31740833).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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