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PYY

This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa.
Full Name
peptide YY
Function
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
Biological Process
Biological Process feeding behaviorManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intestinal epithelial cell differentiationManual Assertion Based On ExperimentTAS:GO_Central
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
PTM
The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).
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Anti-PYY antibodies

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Rabbit Anti-PYY Recombinant Antibody (D1K3Q) (CBMAB-CP2151-LY)

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Target: PYY
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: D1K3Q
Application*: P, IF
Datasheet SDS

Mouse Anti-PYY Recombinant Antibody (BA0419) (CBMAB-0764CQ)

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Target: PYY
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: BA0419
Application*: E, E
Datasheet SDS

Mouse Anti-PYY Recombinant Antibody (CBYC-P812) (CBMAB-P3586-YC)

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Target: PYY
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P812
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-PYY Recombinant Antibody (CBYC-P811) (CBMAB-P3585-YC)

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Target: PYY
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYC-P811
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-PYY Recombinant Antibody (RPY-B12) (CBMAB-P3584-YC)

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Target: PYY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: RPY-B12
Application*: WB, E, IC, IF
Datasheet SDS

Mouse Anti-PYY Recombinant Antibody (CBYC-P810) (CBMAB-P3583-YC)

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Target: PYY
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYC-P810
Application*: E, WB
Datasheet SDS

Mouse Anti-PYY Recombinant Antibody (13A141) (CBMAB-P3582-YC)

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Target: PYY
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 13A141
Application*: E, IH
Datasheet SDS

Mouse Anti-PYY Recombinant Antibody (NA) (CBMAB-AO914LY)

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Target: PYY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NA
Application*: ELISA, IHC
Datasheet SDS

Mouse Anti-PYY Recombinant Antibody (1) (CBMAB-0765CQ)

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Target: PYY
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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