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PYY

This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa.
Full Name
peptide YY
Function
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
Biological Process
Biological Process feeding behaviorManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intestinal epithelial cell differentiationManual Assertion Based On ExperimentTAS:GO_Central
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
PTM
The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).

Anti-PYY antibodies

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Target: PYY
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1
Application*: E
Target: PYY
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: BA0419
Application*: E, E
Target: PYY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NA
Application*: ELISA, IHC
Target: PYY
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: D1K3Q
Application*: P, IF
Target: PYY
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P812
Application*: WB, IC, P, C, E
Target: PYY
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYC-P811
Application*: WB, IC, P, C, E
Target: PYY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: RPY-B12
Application*: WB, E, IC, IF
Target: PYY
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYC-P810
Application*: E, WB
Target: PYY
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 13A141
Application*: E, IH
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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