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ROPN1

ROPN1 is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protei

Full Name

ropporin, rhophilin associated protein 1

Function

Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.

Biological Process

Biological Process cilium organizationISS:UniProtKB
Biological Process flagellated sperm motilityISS:UniProtKB
Biological Process protein localization to ciliumISS:UniProtKB
Biological Process regulation of protein phosphorylationISS:UniProtKB
Biological Process sperm capacitationISS:UniProtKB

Cellular Location

Cell projection, cilium, flagellum
In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.

PTM

Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.

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Anti-ROPN1 antibodies

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Mouse Anti-ROPN1 Recombinant Antibody (CBCNR-657) (CBMAB-R3147-CN)

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Target: ROPN1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBCNR-657

Application*: E, WB, P

Mouse Anti-ROPN1 Recombinant Antibody (CBCNR-656) (CBMAB-R3146-CN)

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Target: ROPN1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBCNR-656

Application*: WB

Mouse Anti-ROPN1 Recombinant Antibody (4E11) (CBMAB-R3145-CN)

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Target: ROPN1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4E11

Application*: E, IH, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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