ROPN1

ROPN1 is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protei
Full Name
ropporin, rhophilin associated protein 1
Function
Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
Biological Process
Biological Process cilium organizationISS:UniProtKB
Biological Process flagellated sperm motilityISS:UniProtKB
Biological Process protein localization to ciliumISS:UniProtKB
Biological Process regulation of protein phosphorylationISS:UniProtKB
Biological Process sperm capacitationISS:UniProtKB
Cellular Location
Cell projection, cilium, flagellum
In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.
PTM
Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.
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Anti-ROPN1 antibodies

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Mouse Anti-ROPN1 Recombinant Antibody (CBCNR-657) (CBMAB-R3147-CN)

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Target: ROPN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBCNR-657
Application*: E, WB, P
Datasheet SDS

Mouse Anti-ROPN1 Recombinant Antibody (CBCNR-656) (CBMAB-R3146-CN)

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Target: ROPN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBCNR-656
Application*: WB
Datasheet SDS

Mouse Anti-ROPN1 Recombinant Antibody (4E11) (CBMAB-R3145-CN)

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Target: ROPN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4E11
Application*: E, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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