Mouse Anti-ROPN1 Recombinant Antibody (4E11) (CBMAB-R3145-CN)

Name: Mouse Anti-ROPN1 Recombinant Antibody (4E11)
SKU: CBMAB-R3145-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

4E11

Application

ELISA, IHC, WB

Immunogen

Full length recombinant corresponding to aa. 1-121 from human ROPN1 (H15413) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

ropporin, rhophilin associated protein 1

Introduction

The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

Entrez Gene ID

54763

UniProt ID

Q9HAT0

Alternative Names

Rhophilin Associated Tail Protein 1; Cancer/Testis Antigen 91; Ropporin, Rhophilin Associated Protein 1; Rhophilin-Associated Protein 1A; ROPN1A; CT91; Testis Secretory Sperm-Binding Protein Li 239w;

Function

Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.

Biological Process

Biological Process cilium organizationISS:UniProtKB
Biological Process flagellated sperm motilityISS:UniProtKB
Biological Process protein localization to ciliumISS:UniProtKB
Biological Process regulation of protein phosphorylationISS:UniProtKB
Biological Process sperm capacitationISS:UniProtKB

Cellular Location

Cell projection, cilium, flagellum
In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.

PTM

Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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