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Mouse Anti-ROPN1 Recombinant Antibody (4E11) (CBMAB-R3145-CN)

This product is a Mouse antibody that recognizes ROPN1. The antibody 4E11 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all ROPN1 antibodies
Published Data
Fig. 1 Localization and expression characteristics of ropporin protein in the testis of fertile by immunohistochemistry.
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Fig. 2 Localization and expression characteristics of ropporin protein in human ejaculated sperm by immunoflurescence.
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Fig. 3 Western blot
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E11
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa. 1-121 from human ROPN1 (H15413) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ropporin, rhophilin associated protein 1
Introduction
The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Entrez Gene ID
54763
UniProt ID
Q9HAT0
Alternative Names
Rhophilin Associated Tail Protein 1; Cancer/Testis Antigen 91; Ropporin, Rhophilin Associated Protein 1; Rhophilin-Associated Protein 1A; ROPN1A; CT91; Testis Secretory Sperm-Binding Protein Li 239w;
Function
Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
Biological Process
Biological Process cilium organizationISS:UniProtKB
Biological Process flagellated sperm motilityISS:UniProtKB
Biological Process protein localization to ciliumISS:UniProtKB
Biological Process regulation of protein phosphorylationISS:UniProtKB
Biological Process sperm capacitationISS:UniProtKB
Cellular Location
Cell projection, cilium, flagellum
In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.
PTM
Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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