S1PR4

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]

Full Name

Sphingosine-1-Phosphate Receptor 4

Function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.

Biological Process

Biological Process activation of phospholipase C activityManual Assertion Based On ExperimentTAS:ProtInc
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-50
Helical: 51-71
Cytoplasmic: 72-84
Helical: 85-105
Extracellular: 106-117
Helical: 118-138
Cytoplasmic: 139-161
Helical: 162-182
Extracellular: 183-206
Helical: 207-227
Cytoplasmic: 228-252
Helical: 253-273
Extracellular: 274-288
Helical: 289-309
Cytoplasmic: 310-384