SCAP1

This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq]

Full Name

src kinase associated phosphoprotein 1

Function

Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.

Biological Process

Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process positive regulation of adaptive immune responseManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of cell-cell adhesion mediated by integrinManual Assertion Based On ExperimentIGI:BHF-UCL
Biological Process positive regulation of cell-matrix adhesionManual Assertion Based On ExperimentIGI:BHF-UCL
Biological Process positive regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of heterotypic cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of integrin activationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of leukocyte cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein localization to plasma membraneIEA:Ensembl
Biological Process T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Cell membrane
Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.

PTM

Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB1. Tyr-232 is dephosphorylated by PTPRC (Probable).