Mouse Anti-SCAP1 Recombinant Antibody (1C11) (CBMAB-A7906-LY)

Name: Mouse Anti-SCAP1 Recombinant Antibody (1C11)
SKU: CBMAB-A7906-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1C11

Application

WB, ELISA

Immunogen

SCAP1 (AAH47870, 1 a.a. ~ 358 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

src kinase associated phosphoprotein 1

Introduction

This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq]

Entrez Gene ID

8631

UniProt ID

Q4V7G1

Alternative Names

SCAP1; SKAP55

Function

Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.

Biological Process

Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process positive regulation of adaptive immune responseManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of cell-cell adhesion mediated by integrinManual Assertion Based On ExperimentIGI:BHF-UCL
Biological Process positive regulation of cell-matrix adhesionManual Assertion Based On ExperimentIGI:BHF-UCL
Biological Process positive regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of heterotypic cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of integrin activationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of leukocyte cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein localization to plasma membraneIEA:Ensembl
Biological Process T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Cell membrane
Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.

PTM

Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB1. Tyr-232 is dephosphorylated by PTPRC (Probable).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-SCAP1 Recombinant Antibody (3D3) (CAT#: CBMAB-A7907-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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