SEC24B

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mutations in this gene have been associated with neural tube defects, and are thought to be a result of a disruption in interactions with the protein encoded by the VANGL planar cell polarity protein 2 (VANGL2) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Full Name

SEC24 Homolog B, COPII Coat Complex Component

Function

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296).
Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296).

Biological Process

Biological Process aorta morphogenesisIEA:Ensembl
Biological Process auditory receptor cell stereocilium organizationIEA:Ensembl
Biological Process cochlear nucleus developmentIEA:Ensembl
Biological Process COPII-coated vesicle cargo loadingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process coronary artery morphogenesisIEA:Ensembl
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportIEA:InterPro
Biological Process lung lobe morphogenesisIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Biological Process outflow tract morphogenesisIEA:Ensembl
Biological Process pulmonary artery morphogenesisIEA:Ensembl
Biological Process regulation of cargo loading into COPII-coated vesicleIEA:Ensembl
Biological Process regulation of establishment of planar polarity involved in neural tube closureIEA:Ensembl

Cellular Location

Cytoplasmic vesicle, COPII-coated vesicle membrane
Endoplasmic reticulum membrane
Cytoplasm, cytosol