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Rabbit Anti-SEC24B Recombinant Antibody (D7D6S) (CBMAB-CP2378-LY)

The product is antibody recognizes SEC24B. The antibody D7D6S immunoassay techniques such as: WB,IP,IF (ICC).
See all SEC24B antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D7D6S
Antibody Isotype
IgG
Application
WB, IP, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr270 of human Sec24B protein.
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SEC24 Homolog B, COPII Coat Complex Component
Introduction
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mutations in this gene have been associated with neural tube defects, and are thought to be a result of a disruption in interactions with the protein encoded by the VANGL planar cell polarity protein 2 (VANGL2) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Entrez Gene ID
Human10427
Monkey697241
UniProt ID
HumanO95487
MonkeyF7E6G0
Alternative Names
SEC24 Homolog B; COPII Coat Complex Component; SEC24 (S. Cerevisiae) Related Gene Family; Member B; SEC24 Family; Member B (S. Cerevisiae); SEC24 Related Gene Family; Member B; Protein Transport Protein Sec24B; SEC24-Related Protein B; SEC24 Family Member B; Secretory Protein 24; SEC24;
Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296).
Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296).
Biological Process
Biological Process aorta morphogenesisIEA:Ensembl
Biological Process auditory receptor cell stereocilium organizationIEA:Ensembl
Biological Process cochlear nucleus developmentIEA:Ensembl
Biological Process COPII-coated vesicle cargo loadingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process coronary artery morphogenesisIEA:Ensembl
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportIEA:InterPro
Biological Process lung lobe morphogenesisIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Biological Process outflow tract morphogenesisIEA:Ensembl
Biological Process pulmonary artery morphogenesisIEA:Ensembl
Biological Process regulation of cargo loading into COPII-coated vesicleIEA:Ensembl
Biological Process regulation of establishment of planar polarity involved in neural tube closureIEA:Ensembl
Cellular Location
Cytoplasmic vesicle, COPII-coated vesicle membrane
Endoplasmic reticulum membrane
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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