SLC25A14

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. The gene product has an N-terminal hydrophobic domain that is not present in other UCPs. Two splice variants have been found for this gene. [provided by RefSeq]

solute carrier family 25 (mitochondrial carrier, brain), member 14

Participates in the mitochondrial proton leak measured in brain mitochondria.

Biological Process aerobic respirationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process malate transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitochondrial transportIEA:InterPro
Biological Process oxaloacetate transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process phosphate ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process succinate transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sulfate transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thiosulfate transportManual Assertion Based On ExperimentIBA:GO_Central

Mitochondrion inner membrane