SLC7A5

SLC7A5 (Solute Carrier Family 7 Member 5) is a protein coding gene. Diseases associated with SLC7A5 include Lysinuric Protein Intolerance and Phenylketonuria. Among its related pathways are Central carbon metabolism in cancer and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology annotations related to this gene include peptide antigen binding and antiporter activity. An important paralog of this gene is SLC7A8.

solute carrier family 7 member 5

The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591).
Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591).
May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity).
May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity).
Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859).
When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567).
Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417).
Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744).
(Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis.

Biological Process amino acid import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process cellular response to glucose starvationIEA:Ensembl
Biological Process cellular response to L-arginineIEA:Ensembl
Biological Process cellular response to lipopolysaccharideIEA:Ensembl
Biological Process isoleucine transportIEA:Ensembl
Biological Process L-leucine import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process L-tryptophan transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process leucine import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process liver regenerationIEA:Ensembl
Biological Process negative regulation of autophagyIEA:Ensembl
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of vascular associated smooth muscle cell apoptotic processIEA:Ensembl
Biological Process neutral amino acid transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process odontogenesisIEA:Ensembl
Biological Process phenylalanine transportManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of cytokine production involved in immune responseManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process positive regulation of glial cell proliferationIEA:Ensembl
Biological Process positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process positive regulation of interleukin-4 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process positive regulation of leucine import across plasma membraneIEA:Ensembl
Biological Process response to hyperoxiaIEA:Ensembl
Biological Process response to muscle activityIEA:Ensembl
Biological Process thyroid hormone transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Biological Process valine transportIEA:Ensembl
Biological Process xenobiotic transportManual Assertion Based On ExperimentIMP:ARUK-UCL

Apical cell membrane
Cell membrane
Lysosome membrane
Located to the plasma membrane by SLC3A2/4F2hc (PubMed:9751058).
Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812).
Recruited to lysosomes by LAPTM4B (PubMed:25998567).
Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity).