SMC5

SMC5 (Structural Maintenance Of Chromosomes 5) is a Protein Coding gene. Among its related pathways are SUMOylation and Metabolism of proteins.

Full Name

Structural Maintenance Of Chromosomes 5

Function

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

Biological Process

Biological Process cell divisionIEA:UniProtKB-KW
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular senescenceManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process chromosome condensationIEA:Ensembl
Biological Process chromosome segregationIEA:Ensembl
Biological Process double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process internal peptidyl-lysine acetylationIEA:Ensembl
Biological Process mitotic cell cycle phase transitionIEA:Ensembl
Biological Process positive regulation of chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of maintenance of mitotic sister chromatid cohesionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to chromosome, centromeric regionIEA:Ensembl
Biological Process protein sumoylation1 PublicationIC:ComplexPortal
Biological Process regulation of telomere maintenance1 PublicationIC:ComplexPortal
Biological Process stem cell population maintenanceIEA:Ensembl
Biological Process telomere maintenance via recombinationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Chromosome
Nucleus, PML body
Chromosome, telomere
Associates with chromatin (PubMed:25931565).
Colocalizes with SMC6 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity).
Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526).
Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565).

PTM

Sumoylated.
Ubiquitinated.
(Microbial infection) SMC5-SMC6 complex is degraded by the activity of Hepatitis B X protein.