SSB

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006 [PubMed 16387655]).[supplied by OMIM
Full Name
Sjogren syndrome antigen B (autoantigen La)
Function
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590).
In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).
Biological Process
Biological Process histone mRNA metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process IRES-dependent viral translational initiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nuclear histone mRNA catabolic processManual Assertion Based On ExperimentIMP:CAFA
Biological Process protein localization to cytoplasmic stress granuleManual Assertion Based On ExperimentIDA:AgBase
Biological Process tRNA 3'-end processingManual Assertion Based On ExperimentIGI:CAFA
Biological Process tRNA 5'-leader removalManual Assertion Based On ExperimentIGI:CAFA
Biological Process tRNA export from nucleusManual Assertion Based On ExperimentIMP:CAFA
Biological Process tRNA modificationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process tRNA processingManual Assertion Based On ExperimentIMP:CAFA
Cellular Location
Nucleus
PTM
Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.
The N-terminus is blocked.
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Anti-SSB antibodies

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Rabbit Anti-SSB Recombinant Antibody (CBYJL-040) (CBMAB-L0070-YJ)

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Target: SSB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYJL-040
Application*: WB, IP
Datasheet SDS

Mouse Anti-SSB Recombinant Antibody (CBYJL-039) (CBMAB-L0069-YJ)

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Target: SSB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rabbit, Rat
Clone: CBYJL-039
Application*: WB, IF
Datasheet SDS

Human Recombinant SSB protein, His Tag-1 (V2LY-0526-LY6950)

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Target: SSB
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-408
Tag: His Tag
Datasheet SDS

Human Recombinant SSB protein, His Tag (V2LY-0526-LY6949)

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Target: SSB
Expressed Host: E. coli
Sequence: Amino Acid: 1-408
Tag: His Tag
Datasheet SDS

Mouse Anti-SSB Recombinant Antibody (3H7-F7) (CBMAB-A8603-LY)

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Target: SSB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H7-F7
Application*: WB, E
Datasheet SDS

Mouse Anti-SSB Recombinant Antibody (1D6-H5) (CBMAB-A8602-LY)

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Target: SSB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D6-H5
Application*: WB, E
Datasheet SDS

Rabbit Anti-SSB (Phosphorylated S366) Polyclonal Antibody (PTM-CBPAB-0996YC) (PTM-CBPAB-0996YC)

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Target: SSB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Application*: IC, IF, IH, WB
Datasheet SDS

Mouse Anti-SSB Recombinant Antibody (CBXS-2865) (CBMAB-S5615-CQ)

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Target: SSB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-2865
Application*: E
Datasheet SDS

Mouse Anti-SSB Recombinant Antibody (CBXS-1658) (CBMAB-S4506-CQ)

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Target: SSB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1658
Application*: WB, IP, P, F, IF
Datasheet SDS

Rabbit Anti-SSB Recombinant Antibody (CBXS-1551) (CBMAB-S4400-CQ)

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Target: SSB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1551
Application*: WB, IP, P, IF
Datasheet SDS

Mouse Anti-SSB Recombinant Antibody (CBXS-5236) (CBMAB-S2451-CQ)

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Target: SSB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: CBXS-5236
Application*: IF, IH, P, IP, WB
Datasheet SDS

Mouse Anti-SSB Recombinant Antibody (CBXS-4949) (CBMAB-S2171-CQ)

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Target: SSB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog
Clone: CBXS-4949
Application*: IF, IH, P, IP, WB
Datasheet SDS

Mouse Anti-SSB Recombinant Antibody (CBXS-4461) (CBMAB-S1703-CQ)

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Target: SSB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: CBXS-4461
Application*: IF, IH, P, WB
Datasheet SDS

Mouse Anti-SSB Recombinant Antibody (CBXS-4037) (CBMAB-S1298-CQ)

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Target: SSB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Monkey, Rat
Clone: CBXS-4037
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SSB Recombinant Antibody (CBXS-4009) (CBMAB-S1270-CQ)

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Target: SSB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4009
Application*: E, WB
Datasheet SDS

Mouse Anti-SSB Recombinant Antibody (CBXS-5966) (CBMAB-S0813-CQ)

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Target: SSB
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Dog, Monkey
Clone: CBXS-5966
Application*: IF, IH, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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