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Mouse Anti-SSB Recombinant Antibody (CBYJL-039) (CBMAB-L0069-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Sjogren Syndrome Antigen B (SSB). The antibody can be used for immunoassay techniques, such as WB, IF.
See all SSB antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Rabbit, Rat
Clone
CBYJL-039
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Human La Protein aa. 179-289.
Specificity
Human, Dog, Rabbit, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 179-289

Target

Full Name
Sjogren syndrome antigen B (autoantigen La)
Introduction
SSB is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein exist in the sera of patients with Sjogren syndrome and systemic lupus erythematosus.
Entrez Gene ID
Human6741
Dog478787
Rat81783
Rabbit100009062
UniProt ID
Alternative Names
Sjogren Syndrome Antigen B; La Autoantigen; La Ribonucleoprotein Domain Family; Member 3; Sjoegren Syndrome Type B Antigen; Lupus La Protein; SS-B; Sjogren Syndrome Antigen B (Autoantigen La); La Ribonucleoprotein
Function
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590).
In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).
Biological Process
Biological Process histone mRNA metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process IRES-dependent viral translational initiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nuclear histone mRNA catabolic processManual Assertion Based On ExperimentIMP:CAFA
Biological Process protein localization to cytoplasmic stress granuleManual Assertion Based On ExperimentIDA:AgBase
Biological Process tRNA 3'-end processingManual Assertion Based On ExperimentIGI:CAFA
Biological Process tRNA 5'-leader removalManual Assertion Based On ExperimentIGI:CAFA
Biological Process tRNA export from nucleusManual Assertion Based On ExperimentIMP:CAFA
Biological Process tRNA modificationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process tRNA processingManual Assertion Based On ExperimentIMP:CAFA
Cellular Location
Nucleus
PTM
Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.
The N-terminus is blocked.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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