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Mouse Anti-SSB Recombinant Antibody (1D6-H5) (CBMAB-A8602-LY)

The product is antibody recognizes SSB. The antibody 1D6-H5 immunoassay techniques such as: WB, ELISA.
See all SSB antibodies
Published Data
Fig.1 Representative western blots of the different conditions and detected proteins.
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Fig.2 External growth stimuli regulate La protein levels through Akt activation.
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Fig.3 The PDGF-induced nuclear export of La is Akt dependent.
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Fig.4 The La protein is associated with translating polyribosomes upon Akt activation.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1D6-H5
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
SSB (AAH01289, 1 a.a. ~ 408 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Sjogren syndrome antigen B (autoantigen La)
Introduction
La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006 [PubMed 16387655]).[supplied by OMIM
Entrez Gene ID
6741
UniProt ID
P05455
Alternative Names
LARP3; La
Function
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590).
In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).
Biological Process
Biological Process histone mRNA metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process IRES-dependent viral translational initiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nuclear histone mRNA catabolic processManual Assertion Based On ExperimentIMP:CAFA
Biological Process protein localization to cytoplasmic stress granuleManual Assertion Based On ExperimentIDA:AgBase
Biological Process tRNA 3'-end processingManual Assertion Based On ExperimentIGI:CAFA
Biological Process tRNA 5'-leader removalManual Assertion Based On ExperimentIGI:CAFA
Biological Process tRNA export from nucleusManual Assertion Based On ExperimentIMP:CAFA
Biological Process tRNA modificationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process tRNA processingManual Assertion Based On ExperimentIMP:CAFA
Cellular Location
Nucleus
PTM
Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.
The N-terminus is blocked.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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