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Mouse Anti-SSB Recombinant Antibody (CBXS-5236) (CBMAB-S2451-CQ)

This product is a mouse antibody that recognizes SSB. The antibody CBXS-5236 can be used for immunoassay techniques such as: IF, IHC, IHC-P, IP, WB.
See all SSB antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Monkey
Clone
CBXS-5236
Antibody Isotype
IgG1
Application
IF, IHC, IHC-P, IP, WB

Basic Information

Immunogen
Protein expressed in 293T cell transfected with human SSB expression vector
Specificity
Human, Dog, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sjogren syndrome antigen B (autoantigen La)
Introduction
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein.
Entrez Gene ID
Human6741
Dog478787
Monkey710344
UniProt ID
HumanP05455
DogA0A8I3S7X5
MonkeyH9FYW7
Alternative Names
Sjogren Syndrome Antigen B; La Autoantigen; La Ribonucleoprotein Domain Family, Member 3; Sjoegren Syndrome Type B Antigen; Lupus La Protein; SS-B; Sjogren Syndrome Antigen B (Autoantigen La); La Ribonucleoprotein;
Function
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590).
In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).
Biological Process
Biological Process histone mRNA metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process IRES-dependent viral translational initiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nuclear histone mRNA catabolic processManual Assertion Based On ExperimentIMP:CAFA
Biological Process protein localization to cytoplasmic stress granuleManual Assertion Based On ExperimentIDA:AgBase
Biological Process tRNA 3'-end processingManual Assertion Based On ExperimentIGI:CAFA
Biological Process tRNA 5'-leader removalManual Assertion Based On ExperimentIGI:CAFA
Biological Process tRNA export from nucleusManual Assertion Based On ExperimentIMP:CAFA
Biological Process tRNA modificationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process tRNA processingManual Assertion Based On ExperimentIMP:CAFA
Cellular Location
Nucleus
PTM
Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.
The N-terminus is blocked.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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