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TCF7L1

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]
Full Name
TCF7L1
Function
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity).
Down-regulates NQO1, leading to increased mitomycin c resistance.
Biological Process
Biological Process canonical Wnt signaling pathwayIBA:GO_Central1 Publication
Biological Process chromatin organizationNAS:UniProtKB2 Publications
Biological Process regulation of DNA-templated transcriptionNAS:UniProtKB2 Publications
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process regulation of Wnt signaling pathwayNAS:UniProtKB2 Publications
Cellular Location
Nucleus
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Anti-TCF7L1 antibodies

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Mouse Anti-Tcf7l1 Recombinant Antibody (CBYJT-2290) (CBMAB-T1399-YJ)

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Target: TCF7L1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYJT-2290
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-Tcf7l1 Recombinant Antibody (CBYJT-2289) (CBMAB-T1398-YJ)

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Target: TCF7L1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYJT-2289
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-TCF7L1 Recombinant Antibody (CBYJT-2288) (CBMAB-T1397-YJ)

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Target: TCF7L1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-2288
Application*: WB
Datasheet SDS

Mouse Anti-TCF7L1 Recombinant Antibody (CBYJT-2287) (CBMAB-T1396-YJ)

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Target: TCF7L1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-2287
Application*: IH
Datasheet SDS

Mouse Anti-TCF7L1 Recombinant Antibody (CBYJT-2286) (CBMAB-T1395-YJ)

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Target: TCF7L1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-2286
Application*: WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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