TCF7L1

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]

TCF7L1

Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity).
Down-regulates NQO1, leading to increased mitomycin c resistance.

Biological Process canonical Wnt signaling pathwayIBA:GO_Central1 Publication
Biological Process chromatin organizationNAS:UniProtKB2 Publications
Biological Process regulation of DNA-templated transcriptionNAS:UniProtKB2 Publications
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process regulation of Wnt signaling pathwayNAS:UniProtKB2 Publications

Nucleus