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Mouse Anti-TCF7L1 Recombinant Antibody (CBYJT-2287) (CBMAB-T1396-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TCF7L1 (Transcription Factor 7 Like 1). The antibody can be used for immunoassay techniques, such as IHC.
See all TCF7L1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2287
Antibody Isotype
IgG2b
Application
IHC

Basic Information

Immunogen
E. coli-derived recombinant human TCF7L1, Lys429-Ser581, Accession # Q9HCS4
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 429-581

Target

Full Name
TCF7L1
Introduction
TCF7L1 is a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. TCF7L1 contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
Entrez Gene ID
83439
UniProt ID
Q9HCS4
Alternative Names
Transcription Factor 7 Like 1; Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box); HMG Box Transcription Factor 3; TCF-3; TCF3; Transcription Factor 7-Like 1
Function
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity).
Down-regulates NQO1, leading to increased mitomycin c resistance.
Biological Process
Biological Process canonical Wnt signaling pathwayIBA:GO_Central1 Publication
Biological Process chromatin organizationNAS:UniProtKB2 Publications
Biological Process regulation of DNA-templated transcriptionNAS:UniProtKB2 Publications
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process regulation of Wnt signaling pathwayNAS:UniProtKB2 Publications
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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