Mouse Anti-TCF7L1 Recombinant Antibody (CBYJT-2287) (CBMAB-T1396-YJ)

Name: Mouse Anti-TCF7L1 Recombinant Antibody (CBYJT-2287)
SKU: CBMAB-T1396-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2287

Application

IHC

Immunogen

E. coli-derived recombinant human TCF7L1, Lys429-Ser581, Accession # Q9HCS4

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, Trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 429-581

More Infomation

Target

Full Name

TCF7L1

Introduction

TCF7L1 is a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. TCF7L1 contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.

Entrez Gene ID

83439

UniProt ID

Q9HCS4

Alternative Names

Transcription Factor 7 Like 1; Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box); HMG Box Transcription Factor 3; TCF-3; TCF3; Transcription Factor 7-Like 1

Function

Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity).
Down-regulates NQO1, leading to increased mitomycin c resistance.

Biological Process

Biological Process canonical Wnt signaling pathwayIBA:GO_Central1 Publication
Biological Process chromatin organizationNAS:UniProtKB2 Publications
Biological Process regulation of DNA-templated transcriptionNAS:UniProtKB2 Publications
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process regulation of Wnt signaling pathwayNAS:UniProtKB2 Publications

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-TCF7L1 Recombinant Antibody (CBYJT-2288) (CAT#: CBMAB-T1397-YJ)

Isotype control

For research use only. Not intended for any clinical use.

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