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Mouse Anti-Tcf7l1 Recombinant Antibody (CBYJT-2290) (CBMAB-T1399-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Tcf7l1 (Transcription Factor 7 Like 1 (T Cell Specific, HMG Box)). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all Tcf7l1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBYJT-2290
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 421-575 of TCF-3 of mouse origin
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 421-575

Target

Full Name
TCF7L1
Introduction
Tcf7l1 functions in processes like Canonical Wnt signaling pathway, regulation of transcription by RNA polymerase II.
Entrez Gene ID
Human83439
Mouse21415
Rat312451
UniProt ID
HumanQ9HCS4
MouseQ9Z1J1
RatF1M1R9
Alternative Names
Tcf3; Tcf-3; bHLHb21
Function
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity).
Down-regulates NQO1, leading to increased mitomycin c resistance.
Biological Process
Biological Process canonical Wnt signaling pathwayIBA:GO_Central1 Publication
Biological Process chromatin organizationNAS:UniProtKB2 Publications
Biological Process regulation of DNA-templated transcriptionNAS:UniProtKB2 Publications
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process regulation of Wnt signaling pathwayNAS:UniProtKB2 Publications
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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