TCP1

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]
Full Name
t-complex 1
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Biological Process binding of sperm to zona pellucidaIEA:Ensembl
Biological Process chaperone-mediated protein foldingIDA:ComplexPortal1 Publication
Biological Process positive regulation of establishment of protein localization to telomereIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein localization to Cajal bodyHMP:BHF-UCL1 Publication
Biological Process positive regulation of telomerase activityIMP:BHF-UCL1 Publication
Biological Process positive regulation of telomerase RNA localization to Cajal bodyIMP:BHF-UCL1 Publication
Biological Process positive regulation of telomere maintenance via telomeraseIMP:BHF-UCL1 Publication
Biological Process protein foldingIDA:FlyBase1 Publication
Biological Process protein stabilizationIMP:BHF-UCL1 Publication
Biological Process regulation of macrophage apoptotic processIEA:Ensembl
Biological Process scaRNA localization to Cajal bodyIMP:BHF-UCL1 Publication
Biological Process toxin transportIEA:Ensembl
Biological Process translocation of peptides or proteins into host cell cytoplasmIEA:Ensembl
Biological Process tubulin complex assemblyNAS:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytosol
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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Anti-TCP1 antibodies

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Mouse Anti-TCP1 Recombinant Antibody (2E8) (CBMAB-BR467LY)

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Target: TCP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E8
Application*: FC
Datasheet SDS

Mouse Anti-TCP1 Recombinant Antibody (2E7) (CBMAB-BR466LY)

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Target: TCP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E7
Application*: FC
Datasheet SDS

Rabbit Anti-TCP1 Recombinant Antibody (D18B6) (CBMAB-CP0162-LY)

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Target: TCP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D18B6
Application*: WB, IP
Datasheet SDS

Recombinant Rat Anti-TCP1 Recombinant Antibody (84a) (CBMAB-XB1115-YC)

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Target: TCP1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 84a
Application*: IP, WB
Datasheet SDS

Recombinant Rat Anti-TCP1 Recombinant Antibody (22b) (CBMAB-XB1113-YC)

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Target: TCP1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Chicken, Dog, Hamster, Rat
Clone: 22b
Application*: E, IP, WB
Datasheet SDS

Recombinant Mouse Anti-Tcp1 Recombinant Antibody (22245A1) (CBMAB-XB1112-YC)

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Target: TCP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Cattle, Chicken, Hamster, Rat, Rabbit, Sheep
Clone: 22245A1
Application*: WB
Datasheet SDS

Rat Anti-TCP1 Recombinant Antibody (CBYY-C2143) (CBMAB-C3581-YY)

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Target: TCP1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Cattle, Dog, Human, Mouse, Pig, Rabbit, Rat, Yeast
Clone: CBYY-C2143
Application*: IP, WB
Datasheet SDS

Rat Anti-Tcp1 Recombinant Antibody (CBYJT-2335) (CBMAB-T1450-YJ)

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Target: Tcp1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBYJT-2335
Application*: IC, IP, WB
Datasheet SDS

Rat Anti-Tcp1 Recombinant Antibody (CBYJT-2334) (CBMAB-T1449-YJ)

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Target: TCP1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Rat, Dog, Chicken, Hamster
Clone: CBYJT-2334
Application*: WB, E, IP
Datasheet SDS

Rat Anti-Tcp1 Recombinant Antibody (23c) (CBMAB-T1448-YJ)

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Target: TCP1
Host: Rat
Antibody Isotype: IgG2c
Specificity: Mouse, Rat, Cattle, Dog, Rabbit, Sheep
Clone: 23c
Application*: WB, IC, IF, IP
Datasheet SDS

Rat Anti-Tcp1 Recombinant Antibody (4E215) (CBMAB-T1446-YJ)

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Target: TCP1
Host: Rat
Antibody Isotype: IgG2c
Specificity: Mouse, Dog, Rat, Hamster, Rabbit, Sheep, Cattle
Clone: 4E215
Application*: IC, IF, IP, WB
Datasheet SDS

Rat Anti-Tcp1 Recombinant Antibody (CBYJT-2333) (CBMAB-T1445-YJ)

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Target: Tcp1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-2333
Application*: WB, IP
Datasheet SDS

Mouse Anti-TCP1 Recombinant Antibody (CBYJT-2331) (CBMAB-T1443-YJ)

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Target: TCP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Frog
Clone: CBYJT-2331
Application*: WB, P
Datasheet SDS

Mouse Anti-TCP1 Recombinant Antibody (2B2-D6) (CBMAB-T1442-YJ)

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Target: TCP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B2-D6
Application*: E, WB, P, IF, IC
Datasheet SDS

Rat Anti-TCP1 Recombinant Antibody (91a) (CBMAB-C9320-LY)

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Target: TCP1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Dog, Human, Mouse, Pig, Rabbit, Rat
Clone: 91a
Application*: IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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