Sign in or Register   Sign in or Register
  |  

Mouse Anti-TCP1 Recombinant Antibody (2B2-D6) (CBMAB-T1442-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TCP1 (T-Complex 1). The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC-P, IF, ICC.
See all TCP1 antibodies
Published Data
Fig.1 CCT chaperonins are required for BBSome assembly.
...View More
Fig.2 CSA co-immunoprecipitation confirms the interaction between endogenous CSA and TCP1.
...View More
Fig.3 Depletion of TCP1 decreases CSA protein abundance.
...View More
Fig.4 DDB1 loss enhances the interaction between TCP1 and CSA.
...View More
Fig.5 CSA harboring patient mutation A160T, A205P, or D266G shows increased binding to TRiC and failure to be incorporated into the CRLCSA complex.
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B2-D6
Antibody Isotype
IgG1, κ
Application
ELISA, WB, IHC-P, IF, ICC

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
t-complex 1
Introduction
TCP1 is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin.
Entrez Gene ID
6950
UniProt ID
P17987
Alternative Names
T-Complex 1; TCP-1-Alpha; CCT-Alpha; CCTA; CCT1; T-Complex Protein 1, Alpha Subunit
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Biological Process binding of sperm to zona pellucidaIEA:Ensembl
Biological Process chaperone-mediated protein foldingIDA:ComplexPortal1 Publication
Biological Process positive regulation of establishment of protein localization to telomereIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein localization to Cajal bodyHMP:BHF-UCL1 Publication
Biological Process positive regulation of telomerase activityIMP:BHF-UCL1 Publication
Biological Process positive regulation of telomerase RNA localization to Cajal bodyIMP:BHF-UCL1 Publication
Biological Process positive regulation of telomere maintenance via telomeraseIMP:BHF-UCL1 Publication
Biological Process protein foldingIDA:FlyBase1 Publication
Biological Process protein stabilizationIMP:BHF-UCL1 Publication
Biological Process regulation of macrophage apoptotic processIEA:Ensembl
Biological Process scaRNA localization to Cajal bodyIMP:BHF-UCL1 Publication
Biological Process toxin transportIEA:Ensembl
Biological Process translocation of peptides or proteins into host cell cytoplasmIEA:Ensembl
Biological Process tubulin complex assemblyNAS:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytosol
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TCP1 Recombinant Antibody (2B2-D6)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare