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Rat Anti-Tcp1 Recombinant Antibody (23c) (CBMAB-T1448-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Tcp1 (T-Complex Protein 1). The antibody can be used for immunoassay techniques, such as WB, ICC, IF, IP.
See all Tcp1 antibodies
Published Data
Fig.1 Validation of the down-regulation of TCP-1 expression in P2X7R shRNA group in vitro and in vivo.
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Fig.2 Validation of the down-regulation of TCP-1 expression in P2X7R shRNA group in vitro and in vivo.
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Fig.3 Validation of the down-regulation of TCP-1 expression in P2X7R shRNA group in vitro and in vivo.
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Fig.4 Validation of the down-regulation of TCP-1 expression in P2X7R shRNA group in vitro and in vivo.
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Summary

Host Animal
Rat
Specificity
Mouse, Rat, Cattle, Dog, Rabbit, Sheep
Clone
23c
Antibody Isotype
IgG2c
Application
WB, ICC, IF, IP

Basic Information

Immunogen
Purified recombinant mouse TCP1 alpha construct encoding the C-terminal half of the 1.8 kb full-length Tcp 1 gene expressed in E. coli
Specificity
Mouse, Rat, Cattle, Dog, Rabbit, Sheep
Antibody Isotype
IgG2c
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
t-complex 1
Introduction
Tcp1 is a component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may function in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
Entrez Gene ID
Dog484064
Mouse21454
Rat24818
Rabbit100302435
Sheep100135437
Cattle512043
UniProt ID
DogA0A8C0NFB2
MouseP11983
RatP28480
RabbitG1U9S7
SheepW5P375
CattleG5E531
Alternative Names
CCT; p63; Cct1; Ccta; TRic; Tp63; Tcp-1; c-cpn; AI528772
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Biological Process binding of sperm to zona pellucidaIEA:Ensembl
Biological Process chaperone-mediated protein foldingIDA:ComplexPortal1 Publication
Biological Process positive regulation of establishment of protein localization to telomereIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein localization to Cajal bodyHMP:BHF-UCL1 Publication
Biological Process positive regulation of telomerase activityIMP:BHF-UCL1 Publication
Biological Process positive regulation of telomerase RNA localization to Cajal bodyIMP:BHF-UCL1 Publication
Biological Process positive regulation of telomere maintenance via telomeraseIMP:BHF-UCL1 Publication
Biological Process protein foldingIDA:FlyBase1 Publication
Biological Process protein stabilizationIMP:BHF-UCL1 Publication
Biological Process regulation of macrophage apoptotic processIEA:Ensembl
Biological Process scaRNA localization to Cajal bodyIMP:BHF-UCL1 Publication
Biological Process toxin transportIEA:Ensembl
Biological Process translocation of peptides or proteins into host cell cytoplasmIEA:Ensembl
Biological Process tubulin complex assemblyNAS:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytosol
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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