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Recombinant Rat Anti-TCP1 Recombinant Antibody (22b) (CBMAB-XB1113-YC)

Provided herein is a Rat Recombinant Antibody against T-Complex 1. The antibody can be used for immunoassay techniques, such as ELISA, IP, WB.
See all TCP1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse, Chicken, Dog, Hamster, Rat
Clone
22b
Antibody Isotype
IgG2a
Application
ELISA, IP, WB

Basic Information

Immunogen
C-terminal half of the full length murine TCP protein
Specificity
Mouse, Chicken, Dog, Hamster, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
t-complex 1
Introduction
TCP1 is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin.
Entrez Gene ID
Dog484064
Mouse21454
Rat24818
Hamster100689476
Chicken421586
UniProt ID
DogA0A8C0NFB2
MouseP11983
RatP28480
HamsterP18279
ChickenQ5ZMG9
Alternative Names
T-Complex 1; TCP-1-Alpha; CCT-Alpha; CCTA; CCT1; T-Complex Protein 1, Alpha Subunit;
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Biological Process binding of sperm to zona pellucidaIEA:Ensembl
Biological Process chaperone-mediated protein foldingIDA:ComplexPortal1 Publication
Biological Process positive regulation of establishment of protein localization to telomereIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein localization to Cajal bodyHMP:BHF-UCL1 Publication
Biological Process positive regulation of telomerase activityIMP:BHF-UCL1 Publication
Biological Process positive regulation of telomerase RNA localization to Cajal bodyIMP:BHF-UCL1 Publication
Biological Process positive regulation of telomere maintenance via telomeraseIMP:BHF-UCL1 Publication
Biological Process protein foldingIDA:FlyBase1 Publication
Biological Process protein stabilizationIMP:BHF-UCL1 Publication
Biological Process regulation of macrophage apoptotic processIEA:Ensembl
Biological Process scaRNA localization to Cajal bodyIMP:BHF-UCL1 Publication
Biological Process toxin transportIEA:Ensembl
Biological Process translocation of peptides or proteins into host cell cytoplasmIEA:Ensembl
Biological Process tubulin complex assemblyNAS:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytosol
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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