TPH1

This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]
Full Name
TPH1 Gene(Protein Coding) Tryptophan Hydroxylase 1
Function
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
Biological Process
Biological Process aromatic amino acid family metabolic process Source:InterPro
Biological Process bone remodeling Source:Ensembl
Biological Process circadian rhythm Source:Ensembl
Biological Process mammary gland alveolus development Source:Ensembl
Biological Process negative regulation of ossification Source:Ensembl
Biological Process platelet degranulation Source:UniProtKB
Biological Process positive regulation of fat cell differentiation Source:Ensembl
Biological Process regulation of hemostasis Source:UniProtKB
Biological Process response to immobilization stress Source:Ensembl
Biological Process serotonin biosynthetic process Source:UniProtKB
Cellular Location
cytosol
neuron projection
PTM
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation.
Phosphorylated; triggering degradation by the proteasome.
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Anti-TPH1 antibodies

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Mouse Anti-TPH1 Recombinant Antibody (Try-63) (CBMAB-AO1036LY)

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Target: TPH1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Rat, Rabbit
Clone: Try-63
Application*: ELISA, WB
Datasheet SDS

Rabbit Anti-TPH1 Recombinant Antibody (D10C10) (CBMAB-CP2832-LY)

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Target: TPH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: D10C10
Application*: WB, IP
Datasheet SDS

Mouse Anti-TPH1 Recombinant Antibody (CBYJT-4328) (CBMAB-T3810-YJ)

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Target: TPH1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Rabbit, Human, Rat
Clone: CBYJT-4328
Application*: WB
Datasheet SDS

Rabbit Anti-TPH1 Recombinant Antibody (CBYJT-4327) (CBMAB-T3809-YJ)

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Target: TPH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYJT-4327
Application*: WB, IP
Datasheet SDS

Mouse Anti-TPH1 Recombinant Antibody (CBYJT-4325) (CBMAB-T3807-YJ)

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Target: TPH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBYJT-4325
Application*: IH, IP, WB
Datasheet SDS

Rabbit Anti-TPH1 Recombinant Antibody (CBYJT-4324) (CBMAB-T3806-YJ)

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Target: TPH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJT-4324
Application*: WB, P, IF, IC, IP, F
Datasheet SDS

Mouse Anti-TPH1 Recombinant Antibody (CBYJT-4323) (CBMAB-T3804-YJ)

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Target: TPH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4323
Application*: WB, IP
Datasheet SDS

Rabbit Anti-TPH1 Recombinant Antibody (CBYJT-4322) (CBMAB-T3803-YJ)

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Target: TPH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4322
Application*: WB, IP
Datasheet SDS

Rabbit Anti-TPH1 Recombinant Antibody (CBYJT-4321) (CBMAB-T3802-YJ)

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Target: TPH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4321
Application*: E
Datasheet SDS

Mouse Anti-TPH1 Monoclonal Antibody (Try-63) (CBMAB-1662-YC)

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Target: TPH1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Rabbit, Rat, Human
Clone: Try-63
Application*: WB
Datasheet SDS

Rabbit Anti-TPH1 Monoclonal Antibody (EP1311Y) (CBMAB-1661-YC)

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Target: TPH1
Host: Rabbit
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: EP1311Y
Application*: F, IC, IF, P, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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