Mouse Anti-TPH1 Recombinant Antibody (CBYJT-4323) (CBMAB-T3804-YJ)

Name: Mouse Anti-TPH1 Recombinant Antibody (CBYJT-4323)
SKU: CBMAB-T3804-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4323

Application

WB, IP

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Tryptophan Hydroxylase 1/TPH-1, Met102-Pro403, Accession # P17752

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, Trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 102-403

More Infomation

Target

Full Name

TPH1 Gene(Protein Coding) Tryptophan Hydroxylase 1

Introduction

TPH1 is a member of the aromatic amino acid hydroxylase family. TPH1 catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in TPH1 have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.

Entrez Gene ID

7166

UniProt ID

P17752

Alternative Names

Tryptophan Hydroxylase 1; Tryptophan Hydroxylase (Tryptophan 5-Monooxygenase); Tryptophan 5-Monooxygenase 1; EC 1.14.16.4; TPRH; TRPH; Indoleacetic Acid-5-Hydroxylase

Function

Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.

Biological Process

Biological Process aromatic amino acid family metabolic process Source:InterPro
Biological Process bone remodeling Source:Ensembl
Biological Process circadian rhythm Source:Ensembl
Biological Process mammary gland alveolus development Source:Ensembl
Biological Process negative regulation of ossification Source:Ensembl
Biological Process platelet degranulation Source:UniProtKB
Biological Process positive regulation of fat cell differentiation Source:Ensembl
Biological Process regulation of hemostasis Source:UniProtKB
Biological Process response to immobilization stress Source:Ensembl
Biological Process serotonin biosynthetic process Source:UniProtKB

Cellular Location

cytosol
neuron projection

PTM

Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation.
Phosphorylated; triggering degradation by the proteasome.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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