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Rabbit Anti-TPH1 Recombinant Antibody (CBYJT-4322) (CBMAB-T3803-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to TPH1 (Tryptophan Hydroxylase 1). The antibody can be used for immunoassay techniques, such as WB, IP.
See all TPH1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJT-4322
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Recombinant Human Tryptophan Hydroxylase 1 / TPH1 Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TPH1 Gene(Protein Coding) Tryptophan Hydroxylase 1
Introduction
TPH1 is a member of the aromatic amino acid hydroxylase family. TPH1 catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in TPH1 have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.
Entrez Gene ID
7166
UniProt ID
P17752
Alternative Names
Tryptophan Hydroxylase 1; Tryptophan Hydroxylase (Tryptophan 5-Monooxygenase); Tryptophan 5-Monooxygenase 1; EC 1.14.16.4; TPRH; TRPH; Indoleacetic Acid-5-Hydroxylase
Function
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
Biological Process
Biological Process aromatic amino acid family metabolic process Source:InterPro
Biological Process bone remodeling Source:Ensembl
Biological Process circadian rhythm Source:Ensembl
Biological Process mammary gland alveolus development Source:Ensembl
Biological Process negative regulation of ossification Source:Ensembl
Biological Process platelet degranulation Source:UniProtKB
Biological Process positive regulation of fat cell differentiation Source:Ensembl
Biological Process regulation of hemostasis Source:UniProtKB
Biological Process response to immobilization stress Source:Ensembl
Biological Process serotonin biosynthetic process Source:UniProtKB
Cellular Location
cytosol
neuron projection
PTM
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation.
Phosphorylated; triggering degradation by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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