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Rabbit Anti-TPH1 Monoclonal Antibody (EP1311Y) (CBMAB-1661-YC)

Provided herein is a rabbit monoclonal antibody against Human TPH1. The antibody, clone EP1311Y, can be used for immunoassay techniques, such as FC, ICC, IF, IHC-P, IP and WB.
See all TPH1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EP1311Y
Antibody Isotype
IgG1
Application
FC, ICC, IF, IHC-P, IP, WB

Basic Information

Immunogen
A synthetic peptide corresponding to residues near the C-terminus of human Tryptophan Hydroxylase
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TPH1 Gene(Protein Coding) Tryptophan Hydroxylase 1
Introduction
TPH1 is a member of the aromatic amino acid hydroxylase family which catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.
Entrez Gene ID
Human7166
Mouse21990
Rat24848
UniProt ID
HumanP17752
MouseP17532
RatP09810
Alternative Names
TPH; TPH2
Function
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
Biological Process
Biological Process aromatic amino acid family metabolic process Source:InterPro
Biological Process bone remodeling Source:Ensembl
Biological Process circadian rhythm Source:Ensembl
Biological Process mammary gland alveolus development Source:Ensembl
Biological Process negative regulation of ossification Source:Ensembl
Biological Process platelet degranulation Source:UniProtKB
Biological Process positive regulation of fat cell differentiation Source:Ensembl
Biological Process regulation of hemostasis Source:UniProtKB
Biological Process response to immobilization stress Source:Ensembl
Biological Process serotonin biosynthetic process Source:UniProtKB
Cellular Location
cytosol
neuron projection
PTM
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation.
Phosphorylated; triggering degradation by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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