TRIM44

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

TRIM44 Tripartite Motif Containing 44

May play a role in the process of differentiation and maturation of neuronal cells (By similarity).
May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807).

Biological Process negative regulation of protein K48-linked ubiquitination Source:BHF-UCL1 Publication
Biological Process positive regulation of cytokine-mediated signaling pathway Source:BHF-UCL1 Publication
Biological Process positive regulation of defense response to virus by host Source:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcription Source:BHF-UCL1 Publication
Biological Process positive regulation of NIK/NF-kappaB signaling Source:BHF-UCL1 Publication
Biological Process protein stabilization Source:BHF-UCL1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:UniProtKB1 Publication

Cytoplasm

Aniridia 3 (AN3):
A form of aniridia, a congenital, bilateral, panocular disorder characterized by complete absence of the iris or extreme iris hypoplasia. Aniridia is not just an isolated defect in iris development but it is associated with macular and optic nerve hypoplasia, cataract, corneal changes, nystagmus. Visual acuity is generally low but is unrelated to the degree of iris hypoplasia. Glaucoma is a secondary problem causing additional visual loss over time.