TRIM63

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]
Full Name
TRIM63 Gene(Protein Coding) Tripartite Motif Containing 63
Function
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Biological Process
Biological Process muscle contraction Source:Ensembl
Biological Process negative regulation of cardiac muscle hypertrophy Source:Ensembl
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process response to electrical stimulus involved in regulation of muscle adaptation Source:UniProtKB
Biological Process response to glucocorticoid Source:Ensembl
Biological Process response to interleukin-1 Source:Ensembl
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process skeletal muscle atrophy Source:Ensembl
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, myofibril, sarcomere, M line
Cytoplasm, myofibril, sarcomere, Z line
Colocalizes with TNNI3 in myocytes (By similarity).
Localizes to the M- and Z-lines in skeletal muscle
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Anti-TRIM63 antibodies

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Mouse Anti-TRIM63 Recombinant Antibody (6G6) (CBMAB-T4368-YJ)

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Target: TRIM63
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6G6
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-TRIM63 Recombinant Antibody (CBYJT-4825) (CBMAB-T4367-YJ)

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Target: TRIM63
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4825
Application*: E, WB
Datasheet SDS

Mouse Anti-TRIM63 Recombinant Antibody (CBFYM-3169) (CBMAB-M3366-FY)

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Target: TRIM63
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYM-3169
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-TRIM63 (AA 293-304) Recombinant Antibody (CBFYM-0207) (CBMAB-M0249-FY)

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Target: TRIM63
Host: Mouse
Specificity: Human
Clone: CBFYM-0207
Application*: F, E, IH, P, IF, IC, MC
Datasheet SDS

Mouse Anti-TRIM63 (AA 293-304) Recombinant Antibody (6H6D4) (CBMAB-M0237-FY)

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Target: TRIM63
Host: Mouse
Specificity: Human
Clone: 6H6D4
Application*: E, IH
Datasheet SDS

Mouse Anti-TRIM63 Recombinant Antibody (CBT4674) (V2LY-0625-LY200)

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Target: TRIM63
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4674
Application*: IH
Datasheet SDS

Mouse Anti-TRIM63 Recombinant Antibody (CBT2617) (V2LY-0625-LY180)

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Target: TRIM63
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2617
Application*: IH, IC, F
Datasheet SDS

TRIM63 Matched Antibody Pair (1280) (APMAB-1280LY)

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Target: TRIM63
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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