Mouse Anti-TRIM63 Recombinant Antibody (6G6) (CBMAB-T4368-YJ)

Name: Mouse Anti-TRIM63 Recombinant Antibody (6G6)
SKU: CBMAB-T4368-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

6G6

Application

ELISA, IF, WB

Immunogen

Partial recombinant corresponding to aa254-353 from human TRIM63 (NP_115977) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 254-353

More Infomation

Target

Full Name

TRIM63 Gene(Protein Coding) Tripartite Motif Containing 63

Introduction

TRIM63 is a member of the RING zinc finger protein family found in striated muscle and iris. TRIM63 is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. TRIM63 plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase.

Entrez Gene ID

84676

UniProt ID

Q969Q1

Alternative Names

Tripartite Motif Containing 63; Striated Muscle RING Zinc Finger Protein; Muscle-Specific RING Finger Protein 1; Iris Ring Finger Protein; Tripartite Motif Containing 63, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase TRIM63; Tripartite Motif-Containing Protein 63; Ring Finger Protein 28; RNF28; MURF1

Function

E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Biological Process

Biological Process muscle contraction Source:Ensembl
Biological Process negative regulation of cardiac muscle hypertrophy Source:Ensembl
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process response to electrical stimulus involved in regulation of muscle adaptation Source:UniProtKB
Biological Process response to glucocorticoid Source:Ensembl
Biological Process response to interleukin-1 Source:Ensembl
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process skeletal muscle atrophy Source:Ensembl

Cellular Location

Cytoplasm
Nucleus
Cytoplasm, myofibril, sarcomere, M line
Cytoplasm, myofibril, sarcomere, Z line
Colocalizes with TNNI3 in myocytes (By similarity).
Localizes to the M- and Z-lines in skeletal muscle

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

TRIM63 Matched Antibody Pair (1280) (CAT#: APMAB-1280LY)

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Mouse Anti-TRIM63 Recombinant Antibody (CBT4674) (CAT#: V2LY-0625-LY200)

Mouse Anti-TRIM63 (AA 293-304) Recombinant Antibody (CBFYM-0207) (CAT#: CBMAB-M0249-FY)

Mouse Anti-TRIM63 Recombinant Antibody (CBYJT-4825) (CAT#: CBMAB-T4367-YJ)

Mouse Anti-TRIM63 (AA 293-304) Recombinant Antibody (6H6D4) (CAT#: CBMAB-M0237-FY)

TRIM63 Matched Antibody Pair (1280) (CAT#: APMAB-1280LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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