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Mouse Anti-TRIM63 Recombinant Antibody (CBYJT-4825) (CBMAB-T4367-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4825
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-453 from human TRIM55 (AAH07750) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-453

Target

Full Name
TRIM63 Gene(Protein Coding) Tripartite Motif Containing 63
Introduction
TRIM63 is a member of the RING zinc finger protein family found in striated muscle and iris. TRIM63 is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. TRIM63 plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase.
Entrez Gene ID
84676
UniProt ID
Q969Q1
Alternative Names
Tripartite Motif Containing 63; Striated Muscle RING Zinc Finger Protein; Muscle-Specific RING Finger Protein 1; Iris Ring Finger Protein; Tripartite Motif Containing 63, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase TRIM63; Tripartite Motif-Containing Protein 63; Ring Finger Protein 28; RNF28; MURF1
Function
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Biological Process
Biological Process muscle contraction Source:Ensembl
Biological Process negative regulation of cardiac muscle hypertrophy Source:Ensembl
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process response to electrical stimulus involved in regulation of muscle adaptation Source:UniProtKB
Biological Process response to glucocorticoid Source:Ensembl
Biological Process response to interleukin-1 Source:Ensembl
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process skeletal muscle atrophy Source:Ensembl
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, myofibril, sarcomere, M line
Cytoplasm, myofibril, sarcomere, Z line
Colocalizes with TNNI3 in myocytes (By similarity).
Localizes to the M- and Z-lines in skeletal muscle
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For research use only. Not intended for any clinical use.

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