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Mouse Anti-TRIM63 Recombinant Antibody (CBT4674) (V2LY-0625-LY200)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4674
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Synthesized peptide of human MuRF1 (AA: 293-304).
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC-P1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TRIM63 Gene(Protein Coding) Tripartite Motif Containing 63
Entrez Gene ID
84676
Function
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Biological Process
Biological Process muscle contraction Source:Ensembl
Biological Process negative regulation of cardiac muscle hypertrophy Source:Ensembl
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process response to electrical stimulus involved in regulation of muscle adaptation Source:UniProtKB
Biological Process response to glucocorticoid Source:Ensembl
Biological Process response to interleukin-1 Source:Ensembl
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process skeletal muscle atrophy Source:Ensembl
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, myofibril, sarcomere, M line
Cytoplasm, myofibril, sarcomere, Z line
Colocalizes with TNNI3 in myocytes (By similarity).
Localizes to the M- and Z-lines in skeletal muscle
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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