TRIM68

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells. [provided by RefSeq]

Full Name

tripartite motif-containing 68

Function

Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.

Biological Process

Biological Process innate immune response Source:GO_Central1 Publication
Biological Process positive regulation of autophagy Source:GO_Central1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:GO_Central1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:GO_Central1 Publication
Biological Process protein autoubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of androgen receptor signaling pathway Source:UniProtKB1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of protein localization Source:GO_Central1 Publication
Biological Process regulation of viral entry into host cell Source:GO_Central1 Publication

Cellular Location

Cytoplasm, perinuclear region
Nucleus
Colocalized with AR in nucleus.

PTM

Auto-ubiquitinated.