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Mouse Anti-TRIM68 Recombinant Antibody (CBYJT-4828) (CBMAB-T4371-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM68 (Tripartite Motif Containing 68). The antibody can be used for immunoassay techniques, such as WB, IP, ELISA.
See all TRIM68 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4828
Antibody Isotype
IgG
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tripartite motif-containing 68
Introduction
TRIM68 is a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family play a role as E3 ubiquitin ligases and are involved in a broad range of biological processes. TRIM68 regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, TRIM68 participates in viral defense regulation as a negative regulator of interferon-beta.
Entrez Gene ID
55128
UniProt ID
Q6AZZ1
Alternative Names
Tripartite Motif Containing 68; RING-Type E3 Ubiquitin Transferase TRIM68; Tripartite Motif-Containing Protein 68; Ring Finger Protein 137; SSA Protein SS-56; RNF137; GC109; SS-56
Function
Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
Biological Process
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process positive regulation of autophagy Source:GO_Central1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:GO_Central1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:GO_Central1 Publication
Biological Process protein autoubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of androgen receptor signaling pathway Source:UniProtKB1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of protein localization Source:GO_Central1 Publication
Biological Process regulation of viral entry into host cell Source:GO_Central1 Publication
Cellular Location
Cytoplasm, perinuclear region
Nucleus
Colocalized with AR in nucleus.
PTM
Auto-ubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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