VAMP3

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]

Full Name

Vesicle Associated Membrane Protein 3

Function

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Biological Process

Biological Process calcium-ion regulated exocytosis Source:Ensembl
Biological Process cellular response to type II interferon Source:Ensembl
Biological Process exocytosis Source:ProtInc1 Publication
Biological Process Golgi to plasma membrane protein transport Source:Ensembl
Biological Process membrane fusion Source:ProtInc1 Publication
Biological Process negative regulation of secretion by cell Source:UniProtKB1 Publication
Biological Process positive regulation of receptor recycling Source:UniProtKB
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process retrograde transport, endosome to Golgi Source:UniProtKB1 Publication
Biological Process SNARE complex assembly Source:GO_Central1 Publication
Biological Process substrate adhesion-dependent cell spreading Source:UniProtKB
Biological Process vesicle docking involved in exocytosis Source:ProtInc1 Publication
Biological Process vesicle fusion Source:GO_Central1 Publication
Biological Process vesicle-mediated transport Source:UniProtKB

Cellular Location

Early endosome membrane
Recycling endosome membrane
Synapse, synaptosome

Topology

Cytoplasmic: 2-77
Helical: 78-98
Vesicular: 99-100

PTM

Ubiquitinated by RNF167 at Lys-66, Lys-68 and Lys-77, regulating the recycling endosome pathway.
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln-|-Phe-60 bond and probably inhibits neurotransmitter release (PubMed:22289120).
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys-|-Leu-43 bond and probably inhibits neurotransmitter release (PubMed:22289120).
Note that humans are not known to be infected by C.botulinum type D.
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln-|-Lys-42 bond and probably inhibits neurotransmitter release (PubMed:22289120).