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Mouse Anti-VAMP3 Recombinant Antibody (CBFYC-3217) (CBMAB-C3294-FY)

This product is mouse antibody that recognizes VAMP3. The antibody CBFYC-3217 can be used for immunoassay techniques such as: WB, ELISA.
See all VAMP3 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
CBFYC-3217
Antibody Isotype
IgG2b
Application
WB, ELISA

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Vesicle Associated Membrane Protein 3
Introduction
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.
Entrez Gene ID
Human9341
Mouse22319
UniProt ID
HumanQ15836
MouseP63024
Alternative Names
Vesicle Associated Membrane Protein 3; Cellubrevin; Synaptobrevin-3; VAMP-3; CEB; Vesicle-Associated Membrane Protein 3; SYB3
Function
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
Biological Process
Biological Process calcium-ion regulated exocytosis Source:Ensembl
Biological Process cellular response to type II interferon Source:Ensembl
Biological Process exocytosis Source:ProtInc1 Publication
Biological Process Golgi to plasma membrane protein transport Source:Ensembl
Biological Process membrane fusion Source:ProtInc1 Publication
Biological Process negative regulation of secretion by cell Source:UniProtKB1 Publication
Biological Process positive regulation of receptor recycling Source:UniProtKB
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process retrograde transport, endosome to Golgi Source:UniProtKB1 Publication
Biological Process SNARE complex assembly Source:GO_Central1 Publication
Biological Process substrate adhesion-dependent cell spreading Source:UniProtKB
Biological Process vesicle docking involved in exocytosis Source:ProtInc1 Publication
Biological Process vesicle fusion Source:GO_Central1 Publication
Biological Process vesicle-mediated transport Source:UniProtKB
Cellular Location
Early endosome membrane
Recycling endosome membrane
Synapse, synaptosome
Topology
Cytoplasmic: 2-77
Helical: 78-98
Vesicular: 99-100
PTM
Ubiquitinated by RNF167 at Lys-66, Lys-68 and Lys-77, regulating the recycling endosome pathway.
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln-|-Phe-60 bond and probably inhibits neurotransmitter release (PubMed:22289120).
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys-|-Leu-43 bond and probably inhibits neurotransmitter release (PubMed:22289120).
Note that humans are not known to be infected by C.botulinum type D.
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln-|-Lys-42 bond and probably inhibits neurotransmitter release (PubMed:22289120).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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