WDR77

The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Full Name
WD Repeat Domain 77
Function
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452).
This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334).
Biological Process
Biological Process epithelial cell proliferation involved in prostate gland development Source:Ensembl
Biological Process histone H4-R3 methylation Source:ComplexPortal1 Publication
Biological Process negative regulation of epithelial cell proliferation involved in prostate gland development Source:Ensembl
Biological Process oocyte axis specification Source:GO_Central1 Publication
Biological Process positive regulation of cell population proliferation Source:Ensembl
Biological Process positive regulation of mRNA splicing, via spliceosome Source:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source:Ensembl
Biological Process spliceosomal snRNP assembly Source:ComplexPortal1 Publication
Cellular Location
Nucleus
Cytoplasm
Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors (PubMed:17437848).
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Anti-WDR77 antibodies

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Mouse Anti-WDR77 Recombinant Antibody (CB464A) (CBMAB-CA464LY)

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Target: WDR77
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CB464A
Application*: ELISA, WB, ICC
Datasheet SDS

Recombinant Mouse Anti-WDR77 Antibody (CBAb248) (CBMAB-Ab248-LY)

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Target: WDR77
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb248
Application*: WB, IC
Datasheet SDS

Rabbit Anti-WDR77 Recombinant Antibody (D56B8) (CBMAB-CP1504-LY)

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Target: WDR77
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D56B8
Application*: WB, IP
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (CBFYM-3181) (CBMAB-M3378-FY)

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Target: WDR77
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYM-3181
Application*: WB, IF
Datasheet SDS

Rabbit Anti-WDR77 Recombinant Antibody (CBWJW-144) (CBMAB-W0290-WJ)

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Target: WDR77
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJW-144
Application*: WB, IP, P, F, IF
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-096) (CBMAB-W0247-WJ)

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Target: WDR77
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJW-096
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-088) (CBMAB-W0239-WJ)

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Target: WDR77
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJW-088
Application*: WB, IC
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-016) (CBMAB-W0173-WJ)

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Target: WDR77
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: CBWJW-016
Application*: WB, IC
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-015) (CBMAB-W0172-WJ)

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Target: WDR77
Host: Mouse
Specificity: Human, Mouse
Clone: CBWJW-015
Application*: WB, IC
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-014) (CBMAB-W0171-WJ)

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Target: WDR77
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJW-014
Application*: E, P
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-013) (CBMAB-W0170-WJ)

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Target: WDR77
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJW-013
Application*: E, WB, P
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-012) (CBMAB-W0169-WJ)

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Target: WDR77
Host: Mouse
Specificity: Human
Clone: CBWJW-012
Application*: IC
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-011) (CBMAB-W0168-WJ)

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Target: WDR77
Host: Mouse
Specificity: Human
Clone: CBWJW-011
Application*: WB, IF
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (8A10-C10-E8) (CBMAB-W0153-WJ)

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Target: WDR77
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 8A10-C10-E8
Application*: WB, IC
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (3F10) (CBMAB-W0098-WJ)

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Target: WDR77
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3F10
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-201) (CBMAB-W0020-WJ)

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Target: WDR77
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJW-201
Application*: ICG, WB
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (
7D5) (V2LY-0725-LY325)

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Target: WDR77
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 7D5
Application*: E, WB, IC
Datasheet SDS

Mouse Anti-WDR77 Recombinant Antibody (A1065) (CBMAB-AP11713LY)

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Target: WDR77
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1065
Application*: ICC, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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