Mouse Anti-WDR77 Recombinant Antibody (CBWJW-012) (CBMAB-W0169-WJ)

Name: Mouse Anti-WDR77 Recombinant Antibody (CBWJW-012)
SKU: CBMAB-W0169-WJ
Rating: 5 (1 reviews)

See all WDR77 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJW-012

Application

ICC

Immunogen

Recombinant full length human MEP50.

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

WD Repeat Domain 77

Introduction

WDR77 is a protein-coding gene encodes the protein which is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. It may be involved in the early stages of prostate cancer. Among its related pathways are Gene Expression and Chromatin organization.

Entrez Gene ID

79084

UniProt ID

Q9BQA1

Alternative Names

p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50

Function

Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452).
This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334).

Biological Process

Biological Process epithelial cell proliferation involved in prostate gland development Source:Ensembl
Biological Process histone H4-R3 methylation Source:ComplexPortal1 Publication
Biological Process negative regulation of epithelial cell proliferation involved in prostate gland development Source:Ensembl
Biological Process oocyte axis specification Source:GO_Central1 Publication
Biological Process positive regulation of cell population proliferation Source:Ensembl
Biological Process positive regulation of mRNA splicing, via spliceosome Source:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source:Ensembl
Biological Process spliceosomal snRNP assembly Source:ComplexPortal1 Publication

Cellular Location

Nucleus
Cytoplasm
Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors (PubMed:17437848).

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-WDR77 Recombinant Antibody (CBWJW-012)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-WDR77 Recombinant Antibody (3F10) (CAT#: CBMAB-W0098-WJ)

Mouse Anti-WDR77 Recombinant Antibody (8A10-C10-E8) (CAT#: CBMAB-W0153-WJ)

Mouse Anti-WDR77 Recombinant Antibody (CBFYM-3181) (CAT#: CBMAB-M3378-FY)

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-015) (CAT#: CBMAB-W0172-WJ)

Mouse Anti-WDR77 Recombinant Antibody (CB464A) (CAT#: CBMAB-CA464LY)

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-088) (CAT#: CBMAB-W0239-WJ)

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-014) (CAT#: CBMAB-W0171-WJ)

Mouse Anti-WDR77 Recombinant Antibody (A1065) (CAT#: CBMAB-AP11713LY)

Mouse Anti-WDR77 Recombinant Antibody (CBWJW-096) (CAT#: CBMAB-W0247-WJ)

Rabbit Anti-WDR77 Recombinant Antibody (D56B8) (CAT#: CBMAB-CP1504-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry