ZBTB49

ZBTB49 (Zinc Finger And BTB Domain Containing 49) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription factor binding. An important paralog of this gene is ZBTB17.Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. Isoform 1: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive). Isoform 3: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.

Full Name

Zinc Finger And BTB Domain Containing 49

Function

Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.
Isoform 1
Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).
Isoform 3
Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.

Biological Process

Biological Process cell cycle Source:UniProtKB-KW
Biological Process negative regulation of cell population proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of cell cycle Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication

Cellular Location

Isoform 1
Cytoplasm
Nucleus
Predominantly located in the nucleus.
Isoform 3
Cytoplasm
Nucleus